Hello, I'm reading an article which explains the genotype profile distribution among the cases of Creutzfeldt-Jakob disease due to the contaminated cadaveric human growth hormone, in the different countries affected by the pandemic. But I'm finding difficulties to understand this paragraph because I don't know this conformational selection model and its association with prions :

" A possible explanation for these superficially contradictory distributions of codon 129 in different outbreaks could be the compatibility of host genotype and strain of the infecting prion, in keeping with the conformational selection model of prion transmission "