Its not well described as of yet. We are doing a study right now trying to add to the knowledge. It also depends on the method used - excite or inhibit activity. You've asked a very big question. With rTMS, we and other groups have seen increases in glutamate in the target region.
See...
Glutamate Alterations Associated With Transcranial Magnetic Stimulation in Youth Depression: A Case Series. J ECT. 2014 May 9.
Eur J Neurosci. 2003 Jun;17(11):2462-8.
For insomnia see - Cell Biochem Biophys. 2013 Sep;67(1):169-73
From what i can see that is it...
Hope it helps.
Frank
Hello,
From basic neurophysiology: all communication in the nervous system is by electrical signals, mediated through ion movements; a currency of communication between neurons is the action potential, generated through the openings of Na+ channels. When the cell accumulates positive charge up to threshold level, then the cell is depolarized. After opening of Na+ channels, K+ leaves the cell resulting in hyperpolarization. When a Na+flow into postsynaptic cell, the result is excitatory; when negatively charged ions flow into postsynaptic cell or cations leave the cell , the result is inhibitory.
TMS uses the principles of electromagnetic induction to induce currents within the brain; these currents can depolarize neurons.
Hope this helps,
T
Pascual Leone 1998 Transcranial magnetic stimulation and neuroplasticity
Kimbrell 1999 Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism
Pelliciarri 2013 Dorsolateral prefrontal transcranial magnetic stimulation in patients with major depression locally affects alpha power of REM sleep
Babbs 2014 A compact theory of magnetic nerve stimulation- predicting how to aim
Karabanov 2015 Consensus Paper- Probing Homeostatic Plasticity of Human Cortex With Non-invasive Transcranial Brain Stimulation
Pashut 2011 Mechanisms of Magnetic Stimulation of Central Nervous System Neurons
Nathou 2015 How do high- and low-frequency repetitive transcranial magnetic stimulations modulate the temporal cortex
Pascual Leone 1998 Transcranial magnetic stimulation and neuroplasticity
Kimbrell 1999 Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism
Pelliciarri 2013 Dorsolateral prefrontal transcranial magnetic stimulation in patients with major depression locally affects alpha power of REM sleep
Babbs 2014 A compact theory of magnetic nerve stimulation- predicting how to aim
Karabanov 2015 Consensus Paper- Probing Homeostatic Plasticity of Human Cortex With Non-invasive Transcranial Brain Stimulation
Pashut 2011 Mechanisms of Magnetic Stimulation of Central Nervous System Neurons
Nathou 2015 How do high- and low-frequency repetitive transcranial magnetic stimulations modulate the temporal cortex
Pascual Leone 1998 Transcranial magnetic stimulation and neuroplasticity
Kimbrell 1999 Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism
Pelliciarri 2013 Dorsolateral prefrontal transcranial magnetic stimulation in patients with major depression locally affects alpha power of REM sleep
Babbs 2014 A compact theory of magnetic nerve stimulation- predicting how to aim
Karabanov 2015 Consensus Paper- Probing Homeostatic Plasticity of Human Cortex With Non-invasive Transcranial Brain Stimulation
Pashut 2011 Mechanisms of Magnetic Stimulation of Central Nervous System Neurons
Nathou 2015 How do high- and low-frequency repetitive transcranial magnetic stimulations modulate the temporal cortex
Our body is a big electromagnet field due to any moving particles in our body are in the electrolytes form. Of cause, a magnet will affect our bodies. However, recent, years, earth magnetic field has weakened tremendously. If you have a grant or want to apply for a grant, I have idea and articles for you to do research. I am too busy to do everything. My main focus is to do prevention and spread "Humanity treatments are Patient's right!" movement. Magnetic therapy is a humane treatment for many diseases. I almost want to write a book about it.
https://universaltcm.com/magnet-therapy/
http://universalenergyhealing.us/head-magnet-treatment-test-applications/
Let me add our recent publication to this. In a sham-controlled study we explain the effects of DLPFC rTMS by comparing an unbiased set of whole-brain networks pre and post stimulation. In short, TMS lead to a specific change in ACC connectivity within a single network (comprising simulation site).
https://doi.org/10.1016/j.neuroimage.2017.09.022
I would suggest that longer-lasting (therapeutic) effects are due to specific network reconfigurations.
https://doi.org/10.1016/j.neuroimage.2017.09.022
Article Towards understanding rTMS mechanism of action: Stimulation ...
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