What will be the next step in autism research after the whole genome sequencing project by Google and Autism Speaks?

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Daniel Helbling

Establish a good model system to properly implicate causative variants unlike previously done exome/genome autism sequencing projects.

Pawel Buczkowicz

Are you referring to this study from SickKids?

http://www.sickkids.ca/AboutSickKids/Newsroom/Past-News/2015/Largest-genome-sequencing-study-finds-surprises-siblings-autism-may-have-different-genetic-causes.html

http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3792.html#author-information

If more researchers have access to all of that data, it will hopefully lead to more discoveries. This is like the 1000 genomes project for ASD. It's an exciting time in genetics research. I still think we should approach next-gen sequencing in the clinic with some degree of caution (not only for autism but other disorders and diseases as well), but it is the future of 'personalized medicine'.

I agree with Daniel that after all the dust has settled, robust model systems will need to be developed to test the wealth of data that will be generated from this project.