What novel biomarkers can aid in the early detection and risk stratification of arrhythmia patients?
Hello Dr Tajinder Kumar Saini
One way I think of it is:
1. biomarkers of myocardial injury - troponin
2. overload - B-type natriuretic peptides (BNP)
3. fibrosis/adverse remodeling - galectin-3 (Gal-3), Growth differentiation factor 15 (GDF-15), soluble suppression of tumorigenicity (sST2))
4. inflammation (Interleukins, Gal-3, CRP)
Prolonged QTc interval has been found in association with cytokine levels, such as tumor necrosis factor-α (TNF-α), and interleukin (IL)-6.
Others might include IL-8, IL-10, IL-1β, myeloperoxidase and CRP
Here's an article specifically on AF:
Article Protein Biomarkers and Risk of Atrial Fibrillation: The Fram...
I'm not sure there are any. Troponin nonspecifically reflects myofiber injury and is not a predictor of subsequent arrhythmias.
Troponin is a biomarker for myofibre injury. There are differing types of Troponin, for skeletal and smooth muscle. However is a specific Troponin for Cardiac Muscle (Combination of Smooth and Skeletal muscle). Original study in 1987 by Sharma and Whyte : Ironheart, looking at the specificity of cardiac troponins in ultra endurance athletes. This paved the way for the Cardiac Specific Troponins that we use today
Troponin has no ability to "aid in the early detection or risk stratification of arrhythmia patients."
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