What might be the probable reason for the signal enhancement in LC-MS tandem mass spectrometry ?

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Mukhtar A Kareem Jaderson

You answered the question yourself. The presence of the matrix is the reason for the enhancement.

Michal Gorka

If you use the same mobile phase and you see a difference in ionization for your specific compund in a matrix and your standard in any other solution the answer is simple - matrix.

Isam Eldin Hussein Elgailani

Please look at the following below links which may help you in your analysis:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395588/pdf/216_2017_Article_255.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937529/pdf/nihms931855.pdf

Thanks