Paul it depends if you focus more on CNS inflammation, remyelinantion/myelin protection, axon de- and regeneration or protection of the neuronal soma. Models for all of these processes are available. Cuprizone and lysolecithin models are commonly used to study remyelination, models with massive macrophage/microglia inflammation in cortex, spinal cord or optic nerve are great models to study pathological activation of these cells in focal EAE models. Axon degeneration, axon regeneration and axon protection can be studied in optic nerve injury models, SCI models, and focal EAE models. Many EAE models enable neuroprotective analysis.

Gareth, I agree. This is a very interesting mouse EAE model and I have a strong interest in it. Already read your paper you mentioned.

Dear Gareth, dear Bernhard

thanks for sharing your insights with kind regards Paul

In my opinion the best model for screening compounds for multiple sclerosis treatment is relapsing remitting model of EAE.

Gareth, could you spicify the main point for the shortcomings of the C57 model.

Thanks

Thanks a lot Gareth. Totally agree, is the best model for this MS type....with few treatments by the moment