Different type of scaffolds are used for regeneration cartilage, bone and several other tissues. Every researcher at the end of the day and at the bottom of the paper suggest that his scaffold is the best so please help me out which one is really the suitable and best as far as cartilage is concerned.
There are lot of bio materials available for cartilage regeneration. But the selection of suitable biomaterial is the main challenge in this filed. Each researcher may think in different angle such that regenerated tissue should mimic the native tissue. The main criteria for selection of material is its mechanical property , biocompatibility and biodegradability. Each material behaviour is different for example PCL has mechanical property suitable for cartilage TE, minimum 2 years of degradation period, good compatibility and FDA approved. But if you have to achieve these properties the concentration of polymer and the preparation methods also have an important role.
well i wish to go for the silk scaffolds so which blend and which type will be suitable then. As we have many types and each type has its own mechanical property as well as biocompatibility and biodegradability as you mentioned. Apart from that there is also a way of blending the silk fibroin with several type of materials available like alginate, agarose, chitosan etc. Keeping both aspects in mind, what will you suggest?
Yes as you told Silk can be blended with other polymers. So the selection of blend polymer is a crucial part. First you have to find out the qualities of silk that suites for cartilage tissue engineering and what is its demerits. Then you can select a polymer that can compensate the demerit. One such blend that we have prepared is
'Silk–PVA' Hybrid Nanofibrous Scaffolds for Enhanced Primary Human Meniscal Cell Proliferation.
Like this you can make lot of polymer blend s/
I am sure you can find tonnes of paper on the different types of scaffold used for cartilage tissue engineering. I think you need to decide what type of cells are you going to use? Is it MSCs or primary chondrocytes and depending upon that chose your materials. Silk with chitosan would work well for both, Remember its always good have higher mechanical strength along with biodegradability.
Yeah I have that two points in my mind mechanical strength as well as biodegradability. I will go for mesenchymal cells as I have the plan to check invivo too
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