Brazil insists on using chloroquine as a miracle drug for COVID-19, but it is something that has already been overcome by the rest of the world. What do you think of that?
Lucindo José Quintans-Júnior It hasn't been proven effective in Covid-19 infection by multiple trials. So, its better not to use at least in Covid-19 infection.
"In the face of the rapid development of this epidemic, how to improve the cure rate, find effective drugs against the virus, has been the most urgent problem. CQ was found to block COVID-19 infected Vero E6 cells in vitro (Al-Bari, 2020), with a 90%-maximal effective concentration (EC90) of 6.9 μM (Wang et al., 2020), which can be clinically achievable in rheumatoid arthritis patients who usually received 500 mg administration. Consequently, CQ as an achievable and potential candidate drug to conquer the new coronavirus has been put into action in clinical trials in China. So far, the number of clinical trials with CQ against COVID-19 is fourteen in China, which have never been published before. Naturally, the analog of CQ, hydroxychloroquine (HCQ), shall be gained attention for scientists. Although the price of HCQ is more expensive than CQ, the toxic are lower than CQ (Mackenzie, 1983). Eleven programs of HCQ against COVID-19 have also been carried out in China." The jury is still out on the issue. For a closer look please peruse:
https://www.frontiersin.org/articles/10.3389/fphar.2020.01167/full
on the other hand, testing the known molecules is better to wait for new and really efficient ones...
stay safe
fred
We understand that in a pandemic situation like this people including researchers are bound to test and try different kinds of methods and materials. The psychological beliefs attached to the effectiveness of some of these drugs cannot be pull aside as well. While the underlying therapeutic effects and cellular mechanism of hydroxylchloroquine (HCQ) remain largely unknown, it is said to increase the intracellular pH, interruption of molecular pathways involved in immune activation and reduction of pro-inflammatory cytokines secretion, and inhibits lysosomal activity in antigen presenting cells. Therefore, the strong anti-inflammatory properties of HCQ is likely to play an important role in controlling a viral infection like COVID-19.
Lucindo José Quintans-Júnior It hasn't been proven effective in Covid-19 infection by multiple trials. So, its better not to use at least in Covid-19 infection.
Thank you, for sharing your opinion about this query. It is a controversial topic, especially here in Brazil, where politics has created problems for critical and reflective thinking.
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