Although I've read a lot about thin-film hydration method, I don't really get the critical points of it. Such as, whether we should add water drop wise or the hole water. I'm working on mPEG-PCL copolymer. Besides, I like to know I can use centrifuge to omit the drug which are not loaded in micelles or not.
If someone knows a complete reference about this method, please let me know the citation.
Thanks
Adding water dropwise will definitely effect the stability and the size of your micelles. The major points remains the concentration ratios of surfactant, water and your materials in order to form a stable micelles, basically take guard of CMC and HLB of your materials. Slow, dropwise and steady delivering of water willl make the micelles more stable.
You can use centrifuge to omit the unloaded drug but before that just optimize the RPM speed at which your nave micelles must be stable.
For more details go through these links these may give a little more insight.
http://www.irjponline.com/admin/php/uploads/2104_pdf.pdf
http://pubs.acs.org/doi/abs/10.1021/ie102016r
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