Mitoxantrone is given to patients as 12mg/m2 body surface area. If Molecular weight of Mitoxantrone is 517 then what could be the molar concentration of mitoxantrone in blood plasma in a patient of 70Kg weight and 6 Ft height and blood volume of around 5.6 lit.
Hi, 6ft means 6x30,480 cm -> height is 182,9 cm. Using calculator you can calculate body surface area (in your example according to Mosteller's equation BSA=1,89 m2, according to DuBois's equation BSA=1,91m2), thus BSA is 1,9 m2. In this situation total dose per patient is 12x1,9 = 22,8 mg. If molecular weight is 517 then pts got 0,0441M = 44,1 mM of drug. And at the end molar concentration is calculated as M per L, thus for volume about 5,6L the concentration will be 44,1mM/5.6L =7,875M/L
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