I searched for methods of indole synthesis but most of them need difficult conditions to be obtained. i found fischer indole synthesis method but i didn't found the general procedure. so, i ask for the procedure for fischer indole method or any other simple methods for indole synthesis.
I recommend the Bischler–Möhlau indole synthesis method for aryl-indole synthesis from α-bromo-acetophenone and excess aniline, as of late, milder strategies have been created, like for example the use of lithium bromide as a catalyst and the use of microwave irradiation.
For more info, you can read following articles : 1. Pchalek, K.; Jones, A. W.; Wekking, M. M. T.; Black, D. S. C. (2005). "Synthesis of activated 3-substituted indoles: An optimised one-pot procedure". Tetrahedron. 61: 77.
2. Vara, Yosu; Aldaba, Eneko; Arrieta, Ana; Pizarro, José L.; Arriortua, María I.; Cossío, Fernando P. (2008). "Regiochemistry of the microwave-assisted reaction between aromatic amines and α-bromoketones to yield substituted 1H-indoles". Organic & Biomolecular Chemistry. 6 (10): 1763.
hello, have you tried Bartoli indole synthesis?, but first you'd need to oxidize aniline to nitrobenzene
Follow this publication...efficient way to generate Indoles:
Functionalized indoles are synthezised under mild conditions in a tartaric acid-dimethylurea melt, that serves as the solvent and as the catalyst. Under these reaction conditions, sensitive functional groups such as N-Boc, N-Cbz, or azides are tolerated. S. Gore, S. Baskaran, B. König, Org. Lett., 2012, 14, 4568-4571.
- Badges
- Science method
- Similar topics
- Chemistry, Organic
- Synthesis