not sure on the indication ? chemotherapy, ponv, other ?

Ondansetron seems to a good choice, working well for my pediatric patients even if they use polypharmacy.

A frequently ignored or forgotten but effective medication against nausea and vomiting is highly concentrated oxygen. A meta-analysis on nausea and vomiting showed beneficial effects of oxygen over nitrogen oxide on postoperative nausea and vomiting (PONV) [1]. Supplemental oxygen is inexpensive and safe and could be used as an alternative for preventing postoperative nausea and vomiting [2-4]. Oxygen administration and high arterial oxygen tension may have an antiemetic effect mediated via the central nervous system as a result of decreased dopamine release in carotid bodies [5].

However, a recent study aimed to test the efficacy of supplemental 80 % oxygen during tonsillectomy on postoperative nausea and vomiting in children [6]. In this randomized controlled trial from Tehran, 102 children scheduled for tonsillectomy (±adenoidectomy) under general anesthesia were divided randomly in two groups according to percent of administered oxygen (group 1: 30% oxygen, group 2: 80% oxygen). The incidence of postoperative nausea and vomiting were assessed and compared in 0–2, 2–6 and 6–24 h after surgery. Incidence of post-tonsillectomy nausea and vomiting after 2, 2–6, and 6–24 h was 13.72, 1.96 and 1.96 % for group 1 and 3.92, 0 and 1.96 % in group 2, respectively. There was no statis- tically significant difference between two groups (P = 0.08) but 80 % oxygen was beneficial for reducing postoperative nausea and vomiting in the first 2 h after surgery in group 2.

References

1. Orhan-sungur M, et al. Does supplemental oxygen reduce postoperative nausea and vomiting? A meta-analysis of randomized controlled trials. Anesth Analg 2008; 106(6):1733–1732.

2. Greif R, et al. Sup- plemental oxygen reduces the incidence of postoperative nausea and vomiting. Anesthesiology 1999; 91:1246–1252

3. Goll V, et al. Ondansetron is no more effective than supplemental intraoperative oxygen for prevention of postoperative nausea and vomiting. Anesth Analg 2001; 92:112–117

4. Kabon B, et al. Optimal perioperative oxygen admin- istration. Curr Opin Anesthesiol 2006; 19:11–18

5. Ziavra NV, Yet al. Effect of breathing supplemental oxygen on motion sickness in healthy adults. Mayo Clin Proc 2003; 78:574–578

6. Izadi P, et al. Effect of supplemental oxygen 80 % on post-tonsillectomy nausea and vomiting: a randomized controlled trial. Our Arch Otorhinolaryngol. 2016; 273(5): 1215-1219

Ondastenon FAD approved

Dear Dr. Alosy,

If you wanted to suggest ondansetron instead of "ondastenon", I would suggest to avoid this drug in pediatric patients with epilepsy, as the administration of ondansetron is known to trigger seizures (Singh NN, et al. Ondansetron and seizures. Epilespia 2009; 50(12): 2663-6).

Dear friends. Thanks for sharing information

But to explain my thoughts depending on_

https://www.drugs.com/sfx/zofran-side-effects.html

Uncommon (0.1% to 1%): Seizures, movement disorders/extrapyramidal reactions (oculogyric crisis/dystonic reactions, dyskinesia)

Rare (0.01% to 0.1%): Grand mal seizures

My 15 year experience in pediatric field not recognize as epileptiognic drug inducer