actually particles less than 5 nm are rapidly cleared from the circulation through extravasation or renal clearance and when the size ranges increases to 15 micrometers accumulation of particles may occur, i wish to know is there any required particle size of nano formulation to target various cancer cells...
I would suggest around 100nm, larger than that would be removed by the liver
Depends on your target cancer. Paul is right. in that 100nm is the size used traditionally but depending on what you want to target that might change.
The ability to target/reach a cancerous tissue is not only dependent on the size. With a size between 5 and 200-300 nm it should be possible. Particles below 5 nm can be exretated by renal filtration, bigger particles can be taken up by the RES. But all these features depend a lot on other factors, e.g. surface charge/zeta potential, stealth effect of the particle (PEGylation), etc.
There is a nice review about nanomedicine approved by the authorities or that is in ongoing clinical trials ("Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications" by Witzigmann et al.).
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