In the long run the river wins, but in the cade of the Indus cascade, every few centuries or millenia, a tectonic lanslide may punctuate the flow for decades or more.
Briefly: rapid uplift leads to a deep cut of the river bed into the surrounding rocks. Formed deep canyons, sometimes with waterfalls. Alluvium almost does not accumulate, the eroded material is carried by the river downstream.
Perhaps I will not give direct response. Because I would like to know something about uplift your studied area… You need clear demonstration of it! Sometimes seems uplift and does not an uplift something else (?) Perhaps you have conglomerates (more precisely breccias) in zone of uplift from the uplifting rock units… You have lot pf literature about it… Majorities are explaining them with counting: subduction, obduction (Nidar Ophioltes: http://web.mit.edu/nchat/www/research-tso-morari.shtml... But If existed there subduction: Why the Nidar ophiolites was not subducted? Another observation: two rivers contradict plate tectonics in Himalaya: rivers Indus and Brahmaputra… Another thing have you any information about the sediments layers direction and these layers inclination on direction to“Asian” plate (China)? … As it seems their position will be again contradiction with obduction of Nidar ophiolites… Is it correct that the Strata layers of north part of INDUS has direction with river and inclination perpendicular to river (and bigger than 45 ° (?))- Can you verify it? There, where the river Indus NPHM… Have to be a fault. What is the name of Fault?
The direct response to your question… It seems you are blinded and for this you have made an erroneous question!
Exist another explanation, but for it I need to go to the region for it verifying… I am cheap and ready to help you in the problems resolutions. Such concepts I am never writing down, only directly sharing them..