hello,
I am trying to separate a star shaped siloxane polymer from starting material using column with some luck. Using 70/30 hexane/EA, I can get my product but with a few problems:
1- The desired product elutes last. However, it seems to be very sticky to the column, as it takes a long time to elute, and flash column shows multiple different peaks of the same material
2- NMR shows that the product may be decaying on the column. Would that be possible? and if so, how can it be avoided?
Because there could be strong interactions or no interactions with the stationary phase. In this case, it is due to strong interactions.
Dear Adam da , it strongly depends on the chemical nature of the siloxane you are trying to separate. Please refer to the following link, in order to understand what are the best conditions to elute your starting material. If you choose a "reverse phase" method for a general alkyl-siloxane, using flash chromatography technique you could use C18-reversed phase silica gel for column chromatography (Sigma-Aldrich code: 60756).
https://chem.libretexts.org/Bookshelves/Analytical_Chemistry/Supplemental_Modules_(Analytical_Chemistry)/Instrumental_Analysis/Chromatography/Chromatographic_Columns
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