what is the properties of bilayer scaffold for skin tissue engineering?
Hello Dariush,
As you know skin normally consisted of epidermis and dermis. The top layer, epidermis is non porous and functional as a protection which has keratinocytes. The bottom layer, dermis, is normally thicker, is porous, provide flexibility and strength. This layer is porous and house the fibroblast.
Having the skin structure in mind, the bilayer skin grafts have tried to mimic this natural structure.
For example you can look for Orcel which is a commercialised skin graft product. It has a top layer made of non prous collagen with added keratinocytes and a bottom layer to mimic dermis, which is again made of collagen but it is porous.
I hope it will help
Amin
Hello Dariush,
As you know skin normally consisted of epidermis and dermis. The top layer, epidermis is non porous and functional as a protection which has keratinocytes. The bottom layer, dermis, is normally thicker, is porous, provide flexibility and strength. This layer is porous and house the fibroblast.
Having the skin structure in mind, the bilayer skin grafts have tried to mimic this natural structure.
For example you can look for Orcel which is a commercialised skin graft product. It has a top layer made of non prous collagen with added keratinocytes and a bottom layer to mimic dermis, which is again made of collagen but it is porous.
I hope it will help
Amin
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