I am doing the reaction between substituted aromatic amine and substituted aromatic aldehyde. In this reaction, product i.e. imine has been formed but both the starting materials are present. Reaction does not proceed towards completion. Why is it so? Can anyone suggest the procedure for the complete conversion of both the starting material to product?
Dear Triveni,
Imines are typically prepared by the condensation of primary amines and aldehydes . In terms of mechanism, such reactions proceed via the nucleophilic addition giving a hemiaminal -C(OH)(NHR)- intermediate, followed by an elimination of water to yield the imine. The equilibrium in this reaction usually favors the carbonyl compound and amine, so that azeotropic distillation or use of a dehydrating agent, such as molecular sieves or magnesium sulfate, is required to push the reaction in favor of imine formation.
Hoping this will be helpful,
Rafik
Dears
The reference to my answer depicted 1 day ago is:
https://en.wikipedia.org/wiki/Imine
Rafik
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