What is the most suitable animal model for investigating antitumor potential of PLGA nanoparticles for colorectal cancer?

18 May 2020 0 1K Report

Different animal models are available like Non-Rodent Species(dog), Rodents(Mice, Rat), Western Diet-Induced Rodent Neoplasia, Chemical Induced Models of Colorectal Cancer(Rats and Mice), The ApcMin Mouse, The F344-Pirc Rat, Genetically Modified Mice etc. Which one is best to get best result.

Badges
Science topic

More Goutam Kumar Jena's questions See All

Where can I find the spike protein amino acid sequence of SARS COV-2 variant B.1.1.7?

I need the spike protein amino acid sequence of SARS COV-2 variant B.1.1.7 (also named as VUI 202012/1)

29 December 2020 2,409 3 View

How to identify GC peaks for FAME mix which do not match reference peaks?

Hello, I am analyzing 37 component FAME mix using GC. I have got 37 peaks and 25 of them show expected order and height. However, others are not in the similar order with the reference for same...

22 November 2020 7,033 4 View

I am looking for a suggestion, how to model 3D layer soil profile of pile on Abaqus?

I am working on numerical modelling of the pile on layer soil using Abaqus. I want to do a 3D model of the pile, thus I have used C3D8R solid element to model the soil around the pile. My...

13 October 2020 7,296 3 View

What is the best procedure to extract bast fibre from plant bark having higher lignin content?

I have tried to extract fiber from the plant bark having higher lignin content with all traditional fiber extraction methods as well as treated up to 20% NaOH Solution at 100 Degree C. However...

04 October 2020 8,149 1 View

How to solve characteristic equation of free vibration of beam using "fzero" function in MATLAB ?

Hello every one, I am solving a Euler-Bernoulli Beam equation for a free vibration system. The beam is supported on an elastic soil. To solve the characteristic equation i have use "fzero"...

11 August 2020 8,649 2 View

Name the journals having highest impact factors in science and pharmaceutical science?

What is the name of the journal in science having highest impact factor? and What is the name of the journal having highest impact factor in pharmaceutical sciences?

03 June 2020 7,054 6 View

How much is the EELS plasmon peak reliable for calculating Fermi energy level for alloys and compounds?

In general the low loss electron energy loss peak contain the information about the electronic structure of materials. From free electron model (Drude Model) the plasmon energy is given by a...

26 May 2020 6,315 3 View

A vaccine effective in monkey against corona virus can be 100% effective in human?

An experimental COVID-19 vaccine protected monkeys from pneumonia and prompted a strong immune response in the animals. Vincent Munster at the National Institute of Allergy and Infectious...

15 May 2020 7,939 6 View

What is the difference between drug loading and Entrapmet Efficiency of drug?

During characterization of Nano-particles, i often get confused between these two terms. Please suggest.

23 April 2020 5,178 1 View

Zeta potential of nanoparticles apart from polymers depends on which factors?

Basically i prepared PLGA based nanoparticles by QbD approach. As Zeta potential is a Critical Quality Attributes(CQA) i have to explain the effect of CMAs and CPPs on CQA. Due to PLGA polymer,...

15 April 2020 5,035 5 View

How can I measure MMP-1 protein activity or protein level from liver tissue?

Instead of checking only the mRNA level, I want to check the active protein level of MMP-1 in Liver tissue from mice. How can I do that?

03 March 2021 1,763 2 View

Does Napabucasin soluble in dichloromethane and in ethanol?

I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...

02 March 2021 9,945 3 View

How can we calculate the sample size for rodents for a particular period of time?

How can we calculate the sample size for rodents for a study for one year? Are there any specific protocols to be followed for designing rodent sampling? How long should be the sampling interval...

01 March 2021 1,056 3 View

Would fecal samples stored at -20C for over a year impact metagenomic analysis?

Dear All, I have access to some rodent fecal samples that have been stored at -20C instead of -80C. Anyone have experience with the impact of stowage condition on comparative metagenomic analysis...

01 March 2021 2,512 1 View

Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?

01 March 2021 8,087 3 View

Which cell line should we use to perform biological dosimetry experiments?

We are preparing some experiments based on irradiating cells under different conditions in order to evaluate the effects in terms of DNA damage, genetic expression, etc. As our project is...

01 March 2021 3,355 3 View

IHC on mouse liver hepatocytes?

Can anyone help me choose primary antibodies for mouse liver hepatocytes and also in conjunction Cd8 cells. Also Cd3 cells. I want to look at hepatocytes and adjacent immune cells in mice with...

01 March 2021 6,953 1 View

How to avoid ulcers in s.c. injected tumors ?

Recently, we have injected s.c. B16F10 tumor cells in BL/6 mice. At around 12-15th day some animals showed ulcerations in tumors , with a big hole in the middle (it looks like a volcano). We have...

01 March 2021 9,938 3 View

Is CD44 degraded in lysosome together with hyaluronan after CD44 mediated endocytosis of hyaluronic acid?

Also when RHAMM binds hyaluronic acid, they get internalized, will RHAMM also be degraded? Or both CD44 and RHAMM will be transferred back to the cell membrane? Asking for breast cancer cell line...

01 March 2021 8,169 2 View

Interested to stain mice tissue with WGA 488 conjugate, anybody has a protocol to recommend?

Interested to stain mice brain tissue with WGA 488 conjugate, appreciate if anyone willing to offer me some guidance or suggestions! Thank you!

28 February 2021 3,951 2 View