What is the meaning of "IC50 value within a factor of 2". Please explain the meaning and the statistics, if involved?

Manisha Bhateria @Manisha_Bhateria2

05 May 2016 1 871 Report

Please explain the statistics involved.

Rachumallu Ramakrishna

It comes from this equation.

Ki = IC50 / (S/km+1), similar equation is present for various inhibitions.

If s = km, then denominator becomes 2, then Ki is IC50/2. If S is smaller than k, then IC50 = Ki.

I think Ki = IC50 (s/km+1), so using the same logic Ki = IC50 x 2.

Therefore use IC50/2 to 2 IC50 as range.

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