Please suggest me some good protocol to check the acute and chronic toxicity of any nanoparticles in mice?
In vivo assessment of hepatotoxicity, nephrotoxicity and biodistribution using 3-aminopropyltriethoxysilane-coated magnetic nanoparticles (APTS-MNPs) in ICR mice
http://link.springer.com/article/10.1007%2Fs11434-014-0296-4
A 13-week repeated-dose oral toxicity and bioaccumulation of aluminum oxide nanoparticles in mice
http://link.springer.com/article/10.1007%2Fs00204-014-1256-0
May be you can get some idea from the above mentioned references
Although doses ranging from near detection limit of the instrument to several grams have been used for various nanoparticles to develop dose-response curves, it would be better if we focus on low environmentally relevant dose and investigate toxicity for chronic exposure. Although not in mice, we did a study in daphnia using a low-dose; results are interesting: http://pubs.acs.org/doi/abs/10.1021/es204055c
I completely agree with Lok.
You might try to get to some first calculations / investigations of realistic exposure concentrations. But that highly depends on the exposure route and nanomaterial you're planning to study.
I know that for oral exposure to SiO2 (e.g. DOI: 10.3109/17435390.2010.519836), Ag and TiO2 NPs you can find some literature looking at different scenarios.
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