Diabetes was induced by i.p. injection of streptozotocin and nicotinamide in rats. The trained diabetic rats ran 8-week on treadmill for 45 min at a speed of 24 m/min and a 5% grade.
After 8 weeks of aerobic exercise training, body weight and epididimal fat weight of diabetic rats without changing food intake decreased when compared to non-diabetic rats. How is this matter discussed?
با سلام خدمت خانم دکتر کاظمی،
یکی از نشانه های مدل دیابت در جوندگان همانطور که مستحضر می باشید کاهش شدید بافت چربی و همچنین بروز هیپوگنادیسم می باشد. برخی ترکیبات یا دارو ها می توانند هم قند خون را کنترل کرده و هم از کاهش شدید توده چربی جلوگیری کنند. بنظر بنده کاهش چربی ناحیه گنادها به علت دیابت است و البته تریدمیل نیز می تواند کاهش وزن بدن (ونه کاهش وزن بیضه ها و چربی های اطراف آنرا) تشدید نموده باشد.
با احترام،
Dear Mehran Hosseini
I want to know about the effect of exercise training on BW and FI in diabetic status.
Thanks anyway
Best
Dear Dr Fahimeh,
So what do you expect from weight of rats; increase or decrease? with quick search there is sharp increase of those rats although they did exercise, please find this file link
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937420/pdf/srep29617.pdf
Best regards
Aly R Abdel-Moemin
Dear professor Aly R Abdel-Moemin
Thank you
We expect decrease in body weight and epididimal fat weight of trained-diabetic rats.
Best regards,
Kazemi
Dear Kazemi,
From your comments, I am concluding that you are asking the question 'why does BW and fat decrease while FI remains the same?' I would suggest that this was probably a part of standardising the protocol between control and exercising rats, otherwise you could attribute the reduction in weight loss to a reduction in calorie intake. However, in doing this, you will have a reduced net calorie intake in the exercising rats (ie. exercising rats will have a higher calorie expenditure than controls but still eating the same), which will influence BW and fat composition. A way around this would be to provide a specific kcal intake per animal weight, but this would require separate housing for each animal.
Have you looked into the effects of exercise on Leptin & Ghrelin? I know this is in humans, but if you can access this paper, it could be of use: http://www.ncbi.nlm.nih.gov/pubmed/12324651
Best Wishes,
Kallie
Normally, muscle exercise promotes influx of glucose into myocytes regardless of insulin sensitivity. In either case , healthy and diabetes, the preferable muscle fuel is fatty acids derived from plasma lipoproteins mediated by lipoprotein lipase (in healthy state) and from lipolysis (in diabetic state) mediated by hormone-sensitive lipase. Hence, with muscle exercise depot fat is consumed leading to reduction of body weight and decrease of the epididymal fat in diabetes-induced rats.
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