Metz et al. (International Immunol 2014, and earlier papers) have reported that IDO2 is expressed mainly in APCs, liver, kidney, brain, and placenta. Metz and Prendergast and their colleagues are making a strong case for IDO2's role in immunomodulation, and I'm wondering what is known about the function of IDO2 in neurons and glia. In other words, is it known what role IDO2 plays in parenchymal cells of the organs and tissues where it is expressed? I'm sure this question is sometimes confounded by the presence of IDO1 and TDO, but I'd like to know who, if anyone, is working on this aspect of IDO2 biology. Thanks.
Hi
In human populations, natural variations in IDO2 gene sequence that attenuate enzymatic activity have been reported to influence brain cancer control and adaptive immune responses to the IDO2 protein itself, consistent with the concept that IDO2 is involved in shaping immune tolerance in human beings.
The primary function of IDO1 is associated with conversion of the essential amino acid, tryptophan, into downstream catabolites known as kynurenines. The depletion of tryptophan and/or accumulation of kynurenine has been shown to induce T cell deactivation, apoptosis and/or the induction of immunosuppressive programming via the expression of FoxP3.
In the UniProt database you can find much more about the funktion of IDO Proteins
It is the limiting step in the conversion of tryptophan to serotonin or NAD in the kinurenins pathway. There is controversy whether this enzyme is associated with the establishment of major depression and neuroprogressive damage caused by stress
Buchs Natasha, thank you for your cogent reply to my IDO2 question. I did not know that
"depletion of tryptophan and/or accumulation of kynurenine has been shown to induce T cell deactivation, apoptosis and/or the induction of immunosuppressive programming via the expression of FoxP3."
Can you post the citation for this publication? Thanks.
Daniel, Thanks for taking the time to reply to my IDO2 question. Can you point me to a publication on the controversy about whether IDO2 is involved in depression and stress-induced neural damage?
Check this Roberthttps://doi.org/10.1016/j.jad.2006.07.013
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