Hi, I’am researching on the effect of Rizatriptan on Migraine and I’m a little bit confused. I though Rizatriptan is used in Migraine because it binds to a seratonin receptor so the level of serotonin should be low in Migraine. However, according to this article Article Migraine is associated with high brain 5-HT levels as indexe...
the level of Serotonin is actually high.
Can someone please help me ?
thanks
Rizatriptan is an effective medicine to stop a migraine attack when you have symptoms of gastric paresis and fast progressive pain
Dear Setare,
Not only you, but the whole migraine research fraternity is confused about the role of serotonin in migraine and its link to triptans.
The consensus, which is completely incorrect, is that high serotonin bioavailability causes migraine. But who can or will challenge, consensus.
Manual acupuncture stimulation of GV 20, GB 20, etc. can inhibit the expression of RAMP 1 protein and mRNA in the STN and midbrain, and up-regulate the expression of 5-HT 1 DR in the two brain regions of migraine rats, which may be related to its effect in relieving migraine...
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