What is the effect of increasing iota carrageenan concentration on the drug release in a gastroretentive drug delivery system?

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Raditya Iswandana

Dear Anas Tarik Alhamdany,

To answer your question about iota carrageenan, it depends on your desired mechanism to create a gastroretentive DDS. Most of the published research showed us that iota carrageenan has to be combined by other polymers to give a good gastroretentive property.

The effect of increasing the iota carrageenan concentration will increase in viscosity due to strong crosslinking of iota carrageenan which resulted in strong elastic crosslinking polymeric network.

Perhaps this article can help you:

http://ukjpb.com/article_details.php?id=62

http://journal.ui.ac.id/index.php/science/article/view/1064

Good luck!

Anas Tarik Alhamdany

Dear Raditya Iswandana

Thank you for your answer..The desired action is for sustained release and regarding the gastroretentive property for sure it does not act solely. It always need other polymer to fix its action.. The question is for the mechanism that iota carrageenan works?