ARF can well be chased with fluid challenge and furosemide bolus and infusion . One has to be very careful when the patient lands into diuresis phase and where to make it intermittent and where to stop and monitor serum electrolytes.

Furosemide can not reduce mortality in AKI patients ;

With F Cantartovich and our randomised controlled trial, continuous IV infusion of furosemide had no benefit, and some time may have adverse events ( severe polyuria ) F Cantarovitch et al AJKD 2004.

Our study was included in the Ho's review ( Benefits and risks of furosemide in AKI) Anesthesia 2010.

Unfortunately , despite experimental dara and interesting potential role, furosemide is not usefull in case of SEVERE AKI.