As we know Avian Influenza virus is located at type A group of Influenza viruses. H9N2 sub type of Avian influenza make a lot of trouble for poultry Industry in Asia and Middle east. In some country the admantane drugs use for controlling impact of this disease. Unfortunately these viruses become resist to this group of drugs rapidly.

In the other hand, concern of reassortment and sharing drug resistance genes between this subtype and seasonal flu type A viruses are always a big issue in public health section.

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