I am planing to perform some biological studies using chicks. For this, I am searching for a dose calculation method for this test system. How can I convert a human dose to a chicken dose for a drug?
Hi,
Not easy because birds are not models for human drugs. In consequence in general regulations birds are not mentioned see FDA guidance below (Tab. 1):
https://www.fda.gov/media/72309/download
But if you would like to make a reverse calculation from human to bird then use FDA guidance and this kind of publication (see below and Fig 2b) and then you can find a common denominator between, bird
Yes, I agree with you. To date, many biological studies have been performed on birds. However, I must give you special thanks for sharing these papers to me.
Regards
Islam
The conversion of a human dose to a chicken dose is not straightforward as it depends on various factors such as the pharmacokinetics and pharmacodynamics of the drug, the size and weight of the chicken, and the species-specific differences in drug metabolism.
The most common method to calculate the dose for chickens is based on body surface area (BSA). This is calculated by using the formula: BSA (cm2) = (weight (kg)^(0.67)) x 7,500.
Once the BSA has been calculated, the dose can be determined by multiplying the human dose with the BSA ratio of the chicken to a human. For example, if the human dose is 100 mg, and the BSA ratio is 0.06, the chicken dose would be 6 mg (100 x 0.06).
It is important to note that this method is based on the assumption that the pharmacokinetics and pharmacodynamics of the drug are similar in chickens and humans. However, this is not always the case, and further experimentation may be necessary to determine the correct dose for the chickens.
In conclusion, converting a human dose to a chicken dose requires careful consideration and may involve a combination of experimentation and calculations based on the BSA of the chicken.
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