What is the diluent effect of extraction of Nitrosamine in drug substances?

05 March 2023 0 254 Report

What is the effect of diluent in nitrosamine recovery?

Candesartan Cilexitil is insoluble in water but we are getting good recovery in water and not in methanol for certain nitrosamines (NDIPA, NDPA). Can anyone suggest chemistry behind that?

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