What is the effect of diluent in nitrosamine recovery?
Candesartan Cilexitil is insoluble in water but we are getting good recovery in water and not in methanol for certain nitrosamines (NDIPA, NDPA). Can anyone suggest chemistry behind that?
The effect of diluent on nitrosamine recovery can vary depending on the specific diluent used and the chemical properties of the nitrosamines and drug substance. In some cases, the presence of certain solvents or diluents can enhance the recovery of nitrosamines, while in other cases, they can have the opposite effect and decrease the recovery.
Regarding your specific question about candesartan cilexetil, the reason why you are getting good recovery of certain nitrosamines in water but not in methanol could be due to differences in the solubility and chemical properties of the drug substance and nitrosamines in the two solvents.
Candesartan cilexetil is generally considered to be insoluble in water, but it is possible that certain impurities or components in the drug substance could be soluble in water and thus affect the recovery of nitrosamines. On the other hand, methanol is a more polar solvent that may interact differently with the drug substance and nitrosamines.
In addition, the specific nitrosamines in question, NDIPA and NDPA, have different chemical structures and properties, which could affect their solubility and recovery in different solvents. Without more detailed information about the specific experimental conditions and methods being used, it is difficult to provide a definitive answer.
However, in general, factors such as solvent polarity, pH, and temperature can all affect the solubility and recovery of nitrosamines and other impurities during the extraction process. Careful selection of appropriate solvents and optimization of extraction conditions are important to ensure accurate and reliable measurements of nitrosamines and other impurities in drug substances.
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