Standardization is normally done when you need to determine the actual concentration in a solution and can be done using titration or instrumental method.

Optimization is when you already have the parameters selected and modify it until you get the best result or yield.

Standardization is normally done when you need to determine the actual concentration in a solution and can be done using titration or instrumental method.

Optimization is when you already have the parameters selected and modify it until you get the best result or yield.

Dear Atul Kumar Gupta

In completing Wee Boon Siong's sentences, generally, in analytical chemistry, optimization also includes standardization . In each test, the conditions ( such as : temperature, concentration, time, pH and so on ) for doing it should be optimized. Nevertheless, optimization of methodology, including standardization of technical procedures, as well as its validation.

Good Luck

The parameters of a protocol needs to be standardized or optimized to get best yield.. so does that mean these two can be used interchangeably ??

They should be optimized, one of the most commonly  optimization approaches is one-factor-at-a-time method, please find attached link:

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https://en.wikipedia.org/wiki/One-factor-at-a-time_method

In the simple words: standartizing, you adjust the parameter to the known standarts, and optimizing, you adjust it to the specific conditions.

The process of making something conform to a standard. the process of implementing and developing technical standards 

"training ensured standardization of procedures at all sites"

the action of making the best or most effective use of a situation or resource. maximize compatibility, interoperability, safety, repeatability, or quality.

"companies interested in the optimization of the business"

Thanks for ur suggestions 

In the regulatory community - a standardized analytical method would be a method that was developed using multi-lab validation - thus proving that the method can be run in different labs using different instrumentation, all getting similar results. For environmental methods, drinking water methods, and standard methods for the analysis of drinking water and waste water - these all would refer to a "Standard" method -  an analytical recipe so to speak that could be followed by experienced chemists.  A lab develops the capability to run one of these methods by using the "standardized" protocol.  Optimization would be specific to each laboratory - for example 5 labs could all be running a standardized method but might be using a different gas chromatography column - which would have to be optimized for that procedure.  One lab might use nitrogen gas, and the other helium gas, they would have to optimize the chromatography - in order to run the standardized method.  Going back to the recipe analogy 5 chefs may all have the same "standardized" recipe for baking a cake- but if one chef lived at high altitude that chef would have to "optimize" baking conditions to get the same final result - a correctly baked cake. - 

Hope this helps-

That sounds very well.. Thanks Peter Philbrook for explaining the concept in a comprehensive manner..