What is the criteria for selection of internal standards for the bioanalysis of drugs?

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Cengiz Gokbulut

Hi,

I think there is not any strict criteria for selection of IS. It is better to select a chemically similar compound to analyte for similar recover and retention time. I used marbofloxacin for HPLC analysis of ciprofloxacin. Good luck!

Sunil Kumar Yadava

thanx to every one for nice and useful suggestions