We would like to reach steady-state CSF concentrations of ~1.5 µg/ml Trimethoprim (TMP) in mice over 1-2 weeks. TMP is soluble to 0.4 mg/ml in water/PBS and 50 mg/ml in DMSO.
I would especially appreciate thoughts regarding:
- administration route
- diluent
- frequency/dosing
- anticipated side effects / problems