We would like to reach steady-state CSF concentrations of ~1.5 µg/ml Trimethoprim (TMP) in mice over 1-2 weeks. TMP is soluble to 0.4 mg/ml in water/PBS and 50 mg/ml in DMSO.

I would especially appreciate thoughts regarding:

- administration route

- diluent

- frequency/dosing

- anticipated side effects / problems

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