Depends. Perhaps you should rephrase your question, as there is no "best of all breeds" combination (if there were such a thing, you would not find the high number of different solutions as you do today).

Also, asking for "the best", you'll only get answers like "Java is the best" - "No, C++ rules", which are not helpful.

Questions to consider in your choice:

1. Are legacy systems / components / libraries involved?

2. Do you have budgetary constraints (i.e., does it have to be open source)?

3. Do you have a partnership with a commercial vendor or a policy, where a typical solution framework is preferred, or even mandatory?

4. Do you need a framework for academic purposes, or do you want to commercially develop software (i.e., academic "cleanness" of a framework, vs. "hands-on power" in real-life situations)

5. Which DBMS requirements do you have? Does it have to run on a separate machine? Does it need to support different users? Should it seamlessly integrate into an application? Do you need big data, transactions? Do you need SQL at all?

6. How important is a good IDE? Debugging tools?

7. Last, not least: Availability of people who are familiar with the system (perhaps including yourself) - this might rule out some interesting candidates (typically functional languages).

You see it's not that easy ;-)

Depends. Perhaps you should rephrase your question, as there is no "best of all breeds" combination (if there were such a thing, you would not find the high number of different solutions as you do today).

Also, asking for "the best", you'll only get answers like "Java is the best" - "No, C++ rules", which are not helpful.

Questions to consider in your choice:

1. Are legacy systems / components / libraries involved?

2. Do you have budgetary constraints (i.e., does it have to be open source)?

3. Do you have a partnership with a commercial vendor or a policy, where a typical solution framework is preferred, or even mandatory?

4. Do you need a framework for academic purposes, or do you want to commercially develop software (i.e., academic "cleanness" of a framework, vs. "hands-on power" in real-life situations)

5. Which DBMS requirements do you have? Does it have to run on a separate machine? Does it need to support different users? Should it seamlessly integrate into an application? Do you need big data, transactions? Do you need SQL at all?

6. How important is a good IDE? Debugging tools?

7. Last, not least: Availability of people who are familiar with the system (perhaps including yourself) - this might rule out some interesting candidates (typically functional languages).

You see it's not that easy ;-)

See, I am looking for not one solution but I am glancing at everyone and then would like to select. Speaking in broader terms, I wrote "best" as I am ignoring anything that might hinder the performance of a large scale(500 clients) on-line software with a sufficient requirement of graphics and at the same time heavy work loads.

For programing languaje, I definitly would select java undoubtedly. It's simple, strong and powerfull, and many devices (from microwaves to smartphones) use this language. My second best program language is python, I think that the polyvalence and flexibility are its strong spot. For DBMS i like PostgresSQL, but if i want high performance, i use OracleDMS. Framework is more complicated, I have use Yii and CodeIgniter, yii is stronger but codeigniter is so simple that makes it attractive.

Java+spring+Hibernate+oracle

Depends what you need, JAVA if you want to use your application on different platforms, C++ if you know target platform and you need faster application, FORTRAN or C if you want to send you application in cosmos space etc.

No doubt, Python+Django+MySQL if you want "rapid development and clean, pragmatic design", like the Django's authors said and many developers demonstrate every day.

MS SQL server and DotNet frameworks (C#).

Again, there is no best. There will always be something that is better than the other depending on what use it will be. You can always try and see first which one would be best for your projects.

Because of vast migration towards the open source world in the near future, It's recommended to use JAVA programming language alongside ORACLE RDBMS or NoSQL databases such as Elastic search, MongoDB, HBase, Casandra for dealing with big data. You could utilize the wide spectrum of JAVA-based frameworks and technologies as well as well-documented tutorials corresponding to them, some frameworks and technologies have been stated as follows:

1. Spring ecosystem: Spring Cloud, Spring Transaction, Spring MVC, Spring Date, Spring Boot, Spring Kafka for JMS, ...

2. Object Relational Mapping (ORM) like Hibernate, EclipseLink, ...

3. User Interface(UI) such as, Java Server Faces(JSF), Java Server Page (JSP), Struts, Primefaces, Omnifaces, ...

4. Build and dependencies managements tools includes: Apache MAVEN, Apache Ant, ..

5. Integrated Development Environment(IDE) such as IntelliJ IDE for JAVA programming, furthermore for Oracle: PL SQL, SQL Developer as well as DataGrip.

6. For dealing with Micro Services and routing concepts apply Apache Camel.

7. for messaging queue (Asynchronous Communications or message-oriented middle-ware) in multi-Tier enterprise applications architecture employ message provider such as IBM MQ.

8. for managing your source code use source control such as Git and collaborating tool exploit JIRA.