I think that the best is to study the biofilm, especially since the phenomenon of quorum sensing is the process used in the development of the biofilm, and within the biofilm matrix we will implicitly find various other compounds. That is, studying the biofilm will provide more details compared to studying antibiotic resistance only.
depending on the bacterium that you want to work with, because each bacterium expresses one or more virulence factors that are mediated or controlled by quorum sensing. for example, pyocyanin in P. aeruginosa, violacein in Chromobacterium violaceum etc..
Therefore, if you can inhibit the production of these pigments, it means that you have inhibited quorum sensing.