Trying to find an animal model which you can use to study chronic neuropathic pain in the dorsal column.
These are some papers that can help
1. Araújo-Filho, H. G., Pereira, E. W., Campos, A. R., Quintans-Júnior, L. J., & Quintans, J. S. (2018). Chronic orofacial pain animal models-progress and challenges. Expert opinion on drug discovery, 13(10), 949-964.
2. Jaggi, A. S., Jain, V., & Singh, N. (2011). Animal models of neuropathic pain. Fundamental & clinical pharmacology, 25(1), 1-28.
3. Hossain, M. Z., Unno, S., Ando, H., Masuda, Y., & Kitagawa, J. (2017). Neuron–Glia crosstalk and neuropathic pain: Involvement in the modulation of motor activity in the orofacial region. International journal of molecular sciences, 18(10), 2051.
Hi, actually it depends on your question and model of inducing pain, but mices and rats are good models for pain assessment. it has some protocols for pain induction. its better to fully understood your own question first, then find the best way to answer it.
Chronic constriction injury (CCI), sciatic nerve ligation (SNL), spared nerve injury (SNI), and other similar minor surgeries produce robust models of neuropathic pain in rats and mice.
None.
It is cruel and unusual punishment and should not be inflicted on animals.
I have argued this at Pain Conferences with just smattering of support.
Neuropathic pain is arguably the most debilitating pain with spontaneous triggers the poor animal has no control over or understanding of. Natural responses such as licking likely to trigger pain.. A broken leg will not hurt if an animal lies still - some sense of control. Not so neuropathic pain.
Sorry. Not the answer you wanted.
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