I find this question very interesting. In my emergency department, we use IV saline as a control alongside IV MgSO₄. Previous recommendations have advocated intravenous magnesium sulfate (IVMS) as a safe and effective therapy option for adult patients with severe acute COPD who do not respond to first-line medications.

I have not used magnesium nebulization post-extubation, but there is related research on this topic.

Ni et al. (2022) identified 11 RCTs and reported potentially lower ICU admissions and reduced dyspnea with magnesium inhalation compared to placebo; however, larger studies are needed to provide a more precise estimate of outcomes. I hope this helps you.

Reference:

Ni, H., Aye, S. Z., & Naing, C. (2022). Magnesium sulfate for acute exacerbations of chronic obstructive pulmonary disease. The Cochrane database of systematic reviews, 5(5), CD013506. https://doi.org/10.1002/14651858.CD013506.pub2

Gives a good result

Gives a good result

Gives a good result

Gives a good result

Gives a good result

Gives a good result