Hi Luke, as far as I know, there are two main forms of Hsp90 in human. They are Hsp90-α and Hsp90-β. Hsp90-β acts as a chaperone and is constitutively expressed while Hsp90-α is the stress inducible form and has a key role in wound healing and tumor metastasis. I watched a video of Dr, Wei Li' speech in USC, which talked about his new findings on how the secreted form of Hsp90-α promoted cell invasion. I think you will be interested in watching it! Very inspiring and interesting speech!

http://keckmedia.usc.edu/mediasite/Viewer/?peid=fd62ad054b09441bbd95943ac3834102

And to my opinion, temperature and oxidative stress are two major factors for Hsp90's stress response based on a number of publications on these two factors. Other factors might be radiation, drugs, and heavy metals.

Hope this helps,

Hedy

Hi Luke, as far as I know, there are two main forms of Hsp90 in human. They are Hsp90-α and Hsp90-β. Hsp90-β acts as a chaperone and is constitutively expressed while Hsp90-α is the stress inducible form and has a key role in wound healing and tumor metastasis. I watched a video of Dr, Wei Li' speech in USC, which talked about his new findings on how the secreted form of Hsp90-α promoted cell invasion. I think you will be interested in watching it! Very inspiring and interesting speech!

http://keckmedia.usc.edu/mediasite/Viewer/?peid=fd62ad054b09441bbd95943ac3834102

And to my opinion, temperature and oxidative stress are two major factors for Hsp90's stress response based on a number of publications on these two factors. Other factors might be radiation, drugs, and heavy metals.

Hope this helps,

Hedy