In the PEG hydrogels preparation researchers mostly use acrylyol chloride for PEG acrylation. Is there any other alternative chemical for the preparation of PEG acrylation? Or does any chemical has similar property of acrylyol chloride?
We have carried out a lot of transesterification reactions using methyl / ethyl acrylate and higher alcohols, like butanol, 2-ethylhexanol, octanol, decanol, benzyl alcohol, etc. Catalyst used is a strong acid and the lower alcohol is required to be distilled out of the reaction mixture. You may try this with PEG.
If you are planning to use PEG acrylates for biomedical applications acryloyl chloride is the best. It is easy to prepare PEG acrylates using this method with high efficiency of end group functionalization and so purification is straight forward. For other methods as described by Ashis Ranjan purification may be a problem especially with polymers like PEG. Moreover further reactions or modifications with PEG acrylates is well documented and you don't need to optimize many of them. Also acrylates are more reactive to further polymerization, especially for making hydrogel etc.
Dear all;
you can use the inverse strategy, that is to say, to use an end chlorinated PEG and react it with acrylamide (here you will get an amide link) or with an acrylate (to get an ester link). If you have a PEG-OH you can attach a cyanate (NCO) bearing vinyl monomer (urethane link), also for the same PEG type you can attach acrylonitrile via Ritter reaction. I think the opportunities are very broad. Hope the attached file will help you to find the best option to answer you need. Regards
If you're not attached to using acrylate groups to polymerize your hydrogel, you could use methacrylate groups instead. Methacrylate functionalized PEG will form similar chain-growth polymerized networks to acrylate functionalized PEG, but synthesis of PEG methacrylate can be much simpler. You can use methacrylic anhydride and microwave functionalization, rather than using (meth)acryloyl chloride. We published a JoVE video article on the microwave methacrylation you might find helpful (linked).
http://www.jove.com/video/50890/microwave-assisted-functionalization-poly-ethylene-glycol-on-resin?status=a52896k
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