We can interpret the word "dependence" in two ways. The most common is related to the physical dependence, an old concept that today is used as a synonymous of withdrawal syndrome, that is, physical signs that appears after drug use discontinuation. However, methamphetamine is a drug that cause addiction, which sometimes can be confused with dependence. Addiction is a disorder related to the use of psychoactive substances in which individual show compulsive intake and continuous use despite of adverse consequences. Thus, dependence is a term used to describe only the adaptive state related to drug withdrawal syndrome.
Methamphetamine (METH) dependence refers to addiction. There are physiological dependence and psychological dependence. METH cause tolerance effect. It means that subjects reduced action to a drug following its repeated the same dose use. They need to increase the dose to reach the same effects. So, that's why Meth is a higly addictive drug.
Methamphetamine dependence refers to a state of psychological dependence on the drug methamphetamine. Methamphetamine dependence is associated with significant impairment in health related quality of life, including degraded physical and social functioning. Please go through the following PDF attachments for more details.
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