Both aflatoxin and IBDV cause immunosupression in poultry. Aflatoxins cause lysis T lymphocytes and decrease the CMI, whereas, IBDV destroys the B lymphocytes in the bursa and decrease the humoral immunity.
Both aflatoxin and IBDV cause immunosupression in poultry. Aflatoxins cause lysis T lymphocytes and decrease the CMI, whereas, IBDV destroys the B lymphocytes in the bursa and decrease the humoral immunity.
Thanks Dr Mahdi for the answer. I just want to add that IBDV has a affinity for B lymphocytes of bursa so depending upon the age of the bird infected it can cause temporary ( In birds above 3 weeks of age) or permanent suppression ( in birds below 3 weeks of age) of humoral immunity and is an important cause of vaccination failure in domestic poultry. On the other hand aflatoxins cause temporary damage to the lymphoid organs and therefore cause suppression of both cell mediated and humoral immunity. In addition, the aflatoxins interfere with the synthesis of proteins in the liver. So the aflatoxins also effects the synthesis of gamma- globulins(antibodies) and may suppress the humoral immunity in the birds.
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