Microencapsulation as one of the most important techniques has remarkable effect on probiotic survival. There are several techniques to encapsulation of probiotic bacteria such as spray drying and spray chilling.
Mohammad,
Spray drying you start from a wet suspension of cells. They are dried in a few second and bring to 40 to 60 °c. The stress is then quite high.
Spray cooling you start from a dry suspension of cells in melt material at 60-80 °c. Also stressful.
The way you master each process will control the final viability of cells. It may depend of the process parameters, the type of cells (very important) but also how you prepare and formulate the cells.
Now in application, spray drying beads would dissolve in water and not spray cooling beads
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