Ehtishamul Haq. et al. International Journal of Biological & Pharmaceutical Research. 2014; 5(7): 609-617.
Taseen Gul et al. AMPK: A POTENT TARGET FOR TREATING OBESITY.INTERNATIONAL JOURNAL OF PHARMACEUTICAL, CHEMICAL AND BIOLOGICAL SCIENCES.2013; 3(3). 801-813
AMPKactivated protein kinasecsees to it that the Camp LEVELS ARE HIGHER with higher cAMO levels which ensures and in end the ATP ISTO amp RATIO IS ALTERED AND AFFECTS THE VARIOUS METABOLIC PROVCESSES IUTILIZING Mtorc1 ND 2 nsd is utilizred in lpid metabolism besides the various pathways in insulin signaling pathway like AKT PHOSOPHORYLATION,PIK,akt,IRBETA effect to effect the insulin metabolism .
AMPK is activated once AMP/ATP ratio increases in the cells. This shifts energy machinery from energy consumpotion (e.g. glycogenesis, protein synthesis, lipogenesis and cholesterol synthesis) to energy generation (fatty acid and glucose oxidation). AMPK catalyzes phosphorylation of of HMG CoA- reductase, causing inhibition of cholesterol synthesis. In addition, it reduces the activity of SREBP transcription factor, that regulates expression of lipogenic enzymes genes. For details refer to https://www.themedicalbiochemistrypage.org/php
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