I need to measure pulmonary arterial pressure of wistar rats with pulmonary hypertension induced by monocrotaline. From literature, the instruments and methods described are not totally clear.
Look at his link if it is useful to you.http://www.hellenicjcardiol.com/archive/full_text/2007/4/2007_4_206.pdf
You can place a DSI catheteter either in the right vetricle or pulmonary trunk. Alter natkively--if you're good with ECHO-Doppler--you can Doppler tricsupid regurgitation, assume right atrial pressure is 5 mmHg, and calculate right ventricular peak systolic pressure as: (PRV)-5=4 times peak velocity^2.
It is a routine procedure in my lab. We follow more or less the methods of this article :
http://www.ncbi.nlm.nih.gov.gate2.inist.fr/pubmed/7298418
We use polyurethane catheters, they avoid damaging the vessels and the heart.
you can predict mean pulmonary artery pressure using echo Doppler of the pulmonary artery which is easier to image than tricuspid regurgitation. Use the Mahan equation to predict mPAP from pulmonary artery acceleration time
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