Alzheimer's disease is a progressive disease that destroys memory and other important mental functions. At first, someone with Alzheimer's disease may notice mild confusion and difficulty remembering. Eventually, people with the disease may even forget important people in their lives and undergo dramatic personality changes.
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Alzheimer's is a slowly progressive neurodegenerative disorder, it usually occurs beginning from age 65 yrs, 2ry to deposition of amyloid plaques extracellular and tangles intracellular, such deposits disrupt the neuronal talk to each others causing failure in functions.
First manifestation is usually memory impairment to recent events and as the disease progresses other cognitive functions are lost and at the end the non cognitive functions are lost too.
Causes include low education degrees, hypertension, genetics.
Genetics are those of amyloid protein precursor which is carried on chromosome 21 and preseniline Gene
APP which is on chromosome 21 for example is expressed in excess in down syndrome as it has trisomy in this chromosome and so Alzheimer's is common in down syndrome patients and in earlier age than the known age of Alzheimer's.
A large info is present regarding Alzheimer's and a larger info is to be discovered from this is the serum biomarkers for such disease and other neurodegenerative disorders and this is one of my work with other colleagues.
Nothing! It is the illness from Augusta D. (once case) patients in Uni klinik Munich (48 years old) with confusion and subdelirium, whi died besause decubitus and pneumonia. Kraepellin said she is the patient from dr Alzheimer.
All other is production of pharma industrie and marketing.
Alzheimer’s disease is a progressive, degenerative neurological condition caused by nerve cell death resulting in shrinkage of the brain The symptoms of Alzheimer's disease includes loss of memory, difficulty in learning and concentration, decline in ability to perform routine tasks, loss of language and communication skills, changes in mood and personality, and decreased or poor judgement.
The exact causes of the disease are not yet known. However, it is assumed that a combination of genetic, lifestyle, and environmental factors contribute to the risk of developing of Alzheimer’s disease, which usually occurs after age of 60.
Please have a look at the following RG links.
Article Alzheimer's disease
Article History of Alzheimer's Disease
Article Epidemiology of Alzheimer disease
Article Pathophysiology of Alzheimer's Disease
Article Genetic insights in Alzheimer's disease
Article Recent Progress in Alzheimer’s Disease Research, Part 1: Pathology
It is a progressive degenerative neuropsychiatric disease. A form of senile (usually) dementia, according to Gillespie's defnition. Looking at my 30 year old files, AD occurs in 7-10% of all dementia cases. All the rest are either vascular (60-70%), or metabolic or toxic (including D Pugilistica).
So called "Alzheimer disese" is a presenile dementia na Dr Alzeimer describe only once patient (Augusta D)! The rela name was "the patientin from Dr Alzheimer" or "Dr Alzheimer's patientin".
Once part of so called "AD" are forms of Neurolues (Dementio paralytica - MID), and the other consequences of many other brain and body illnesses (Infection, inflammation, metabolic and endocrine disorders, intoxications, ect.)
Article Advances and considerations in AD tau-targeted immunotherapy
Article Deep Learning to Detect Alzheimer's Disease from Neuroimagin...
Article Cerebral amyloid angiopathy and Alzheimer disease — one pept...
Article A Systematic Review of Longitudinal Studies Which Measure Al...
etc., etc.
Article Cognitive symptoms of Alzheimer's disease: Clinical manageme...
"Alzheimers disease is not diease - it are very diffrenet clinical syndromas wit very different etiology! Augusta D was the pationt from Dr Alzheimer in Munich and Prof. Kraepellin said - she is the patient from Dr Alzheimer! Augusta the had a unclear psycotic state and died from sepsis. APOstmortem Nils described bet amiloids in shes brain (simmilar to ohe chronic infection states). It were in first time PRESENILE syndromas.
Neurons undergo ‘cellular suicide’ in response to amyloid plaques, the tangles of abnormal proteins that accumulate in the brains of people with Alzheimer’s disease. It’s the first clue to a mechanism that has eluded scientists for decades. In the presence of plaques, brain cells increase expression of a gene that triggers programmed cell death. When the gene was blocked, the neurons survived...
https://www.bbc.com/news/health-66816268
Drago Ljubomir,
neurons undergo "cellular suffocation" than suicide.
Hvala vam
Ljubomir Jacić
Scientists have identified two types of brain cell linked to a reduced risk of dementia — even in people who have lots of the amyloid ‘plaques’ that are hallmarks of Alzheimer’s disease. The neurons might have a role in the types of cognitive function that are lost during Alzheimer’s, hinting at future treatments that focus on protecting them...
https://www.nature.com/articles/d41586-023-03012-7
“Someone who has biomarker evidence of amyloid in the brain has [Alzheimer’s] disease, whether they’re symptomatic or not.”
Neuroscientist Clifford Jack Jr is the chair of an Alzheimer’s Association working group that has proposed new criteria for diagnosing the disease on the basis of the amyloid ‘plaques’ that are hallmarks of the disease...
https://www.nytimes.com/2024/03/04/health/alzheimers-amyloid-diagnosis.html?unlocked_article_code=1.aU0.V5rD.8txLA7WTo_7i&smid=url-share
Drago Ljubomir,
Улице твојих погледа Немају краја Ласте из твојих зеница На југ се не селе .......... На небу твојих речи Сунце не залази
Hvala vam
‘Most important letter in dementia research’
"In a brisk but affecting thread, science journalist Tom Whipple revisits the tale of Carol Jennings, whose 1986 letter to neurogeneticist John Hardy outlining her family history of Alzheimer’s jump-started the leading theory of the disease. The letter’s outcome, five years later, was an influential Nature paper identifying a genetic mutation linked to the formation of amyloid plaques in the brain, supporting the idea that amyloid contributes to dementia. Recently, two experimental treatments — the monoclonal antibodies donanemab and lecanemab — that target amyloid have been shown to reduce the cognitive decline associated with Alzheimer’s disease, raising hopes for a new era of effective treatments. Jennings — who began to develop symptoms of Alzheimer's disease in 2008 — died in March, aged 70..."
https://twitter.com/whippletom/status/1787768165268586979
https://www.nature.com/articles/d41586-023-01537-5