I want to crystallize 2,3,4,6-Tetra-O-benzyl-D-galactopyranose (CAS Number 53081-25-7)? What would be a suitable solvent?
Mostly u have to use polar solvents like EtOH, MeOH or may be water? U have to heat it and slowly allow it to recrystalised.
Ha? Did you try on galactose derivative? That fine on glucose, but galactose is smewhat more difficult.
nope, not water............go for non-polar solvent............or a pair of non-polar solvents
Acetone, Chloroform, Dichloromethane, Ether, Ethyl Acetate...I am not an expert I just check a reference...I hope it helps you http://www.usbio.net/item/T2964-40
from what impurities? for non polar, I would start with AcOEt-hex mixtures, give a chance to some bigger ethers, particularly iPr2O or MTBE mixtures with hexane induce nice crystals sometimes. for polar impurities e.g. free galactose, alcohol-water mixtures are mandatory, but particular ratio and alcohol choice is very dependent on PGs and configuration.
If you have solubility problem with only Methanol, then first dissolve the product in Chloroform, filter off undissolved material, distill off solvent and finally precipitate with Methanol
-OH groups are protected by benzyl so you should use apolar solvent such as toluene, hegzane...I think toluene works well
Maybe you want to have a look at our paper, a tutorial about single crystal growth:
https://www.researchgate.net/publication/230751079_Some_thoughts_about_the_single_crystal_growth_of_small_molecules
Article Some thoughts about the single crystal growth of small molecules
I haven't worked with this compound specifically, but found 95% ethanol to be useful for crystallization of a closely related compound (benzyl 2,3,4-tri-O-benzylglucuronate).
Bonjour Arnaud, Question, this compound must be well known, so is it a solid? My first guess would be: it is an oil. if it is a solid crystalisation is let say close to witch craft! look in the literature first for this particular compound, you may find your answer. If you do not find anything, I would start with R-OH (single solvent system), methanol or ethanol... Good luck.
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