What is a multisystem inflammatory syndrome in children (MIS-C)? and who is at risk?
All comments and contributions are welcome.
Dear Dr. Harasit Kumar Paul Thanks a lot for your comment and contribution. Really thanks. Thanks for your kindness and support.
Well, it is a scenario where a child has multiple organs (kidney, liver, sclera of the eye s ) inflammation.. it is important to note that this condition have been identified in Covid-19 infected children.. so children with Covid-19 infected parents or guidians are most at risk.. Scientists around the world are still learning about it.. but i can say from an ongoing research that children who are sickle cell are and its carrier (AS or AC) are likely to get sick and in some cases fatally sick..
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Multisystem inflammatory syndrome in children (MIS-C) is a condition where different body parts can become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs. We do not yet know what causes MIS-C. However, we know that many children with MIS-C had the virus that causes COVID-19, or had been around someone with COVID-19. MIS-C can be serious, even deadly, but most children who were diagnosed with this condition have gotten better with medical care.
The symptoms of this syndrome include:
- Fever
- Abdominal pain
- Vomiting
- Diarrhea
- Neck pain
- Rash
- Bloodshot eyes
- Feeling extra tired
- Also, it should be taken into consideration that not all children have the same symptoms.
Doctors may do certain tests to look for inflammation or other signs of disease. These tests might include:
- Blood tests
- Chest x-ray
- Heart ultrasound (echocardiogram)
- Abdominal ultrasound
Doctors may provide supportive care for symptoms (medicine and/or fluids to make your child feel better) and may use various medicines to treat inflammation. Most children who become ill with MIS-C will need to be treated in the hospital. Some will need to be treated in the pediatric intensive care unit (ICU). Parents or caregivers who have concerns about their child’s health, including concerns about COVID-19 or MIS-C, should call a pediatrician or other healthcare provider immediately. Healthcare providers can follow CDC recommendations to keep children and their parents or caregivers safe if an in-person visit is needed.
CDC is still learning about MIS-C and how it affects children, so we don’t know why some children have gotten sick with MIS-C and others have not. We also do not know if children with certain health conditions are more likely to get MIS-C. These are among the many questions CDC is working to try to understand. All CDC recommendations are based on the best data and science available at the time, and we will update them as we learn more.
Based on what we know about MIS-C, the best way we can protect our children is by taking everyday actions to prevent your child and the entire household from getting the virus that causes COVID-19.
Though children of all ages can become sick with coronavirus disease 2019 (COVID-19), most kids who are infected typically don't become as sick as adults do. Some children who have an active infection with the virus that causes COVID-19 might not show any signs or symptoms at all. Still, we may have heard about a serious inflammatory syndrome in children, including some teenagers, that appears to be linked to COVID-19. It's called multisystem inflammatory syndrome in children (MIS-C). This syndrome is rare, and most children who have it eventually get better with medical care. But some kids rapidly get worse, to the point where their lives are at risk.
https://www.mayoclinic.org/diseases-conditions/coronavirus/in-depth/mis-c-in-children-covid-19/art-20486809
Please have a look at this informative article:
http://www.childrenshospital.org/conditions-and-treatments/conditions/m/mis-c
An antibody test with a positive result means that the child's immune system developed blood proteins (antibodies) that fought the COVID-19 virus. Sometimes this blood test is the only indication that the child was ever infected - meaning the child may have fought the infection without ever having shown signs or symptoms of COVID-19. Still, some children with MIS-C are currently infected with the virus, usually confirmed by detection of the virus on a swab taken from the back of the nose or throat. Many, but not all, children with MIS-C test negative for a current infection with the virus that causes COVID-19. Yet evidence indicates that many of these children were infected with the COVID-19 virus in the past, as shown by positive antibody test results.
Dear Dr. Hassan Izzeddin Sarsak Thanks a lot for your comment and contribution. Really thanks. Thanks for your kindness and support.
MIS-C shares some of the same signs and symptoms as another condition called Kawasaki disease. Kawasaki disease mainly affects children under 5 years of age. It causes inflammation in the walls of blood vessels, particularly those that supply blood to the heart muscle (coronary arteries). Researchers are working to figure out if the two conditions are related or not.
Most children with MIS-C need to be treated in a hospital, and some will need treatment in a pediatric intensive care unit. Treatment usually involves different types of therapies that target the immune system and reduce inflammation. Depending on your child's symptoms and condition, he or she may receive anti-inflammatory drugs and other medications to reduce inflammation in the affected vital organs, such as the heart or kidneys, and protect them from permanent damage. MIS-C is not contagious, but there's a chance that your child could have an active infection with the COVID-19 virus or another type of contagious infection. So the hospital will use infection control measures while caring for your child.
https://www.mayoclinic.org/diseases-conditions/coronavirus/in-depth/mis-c-in-children-covid-19/art-20486809
https://www.yalemedicine.org/conditions/multisystem-inflammatory-syndrome-in-children-mis-c/
https://www.who.int/news-room/commentaries/detail/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19
It is also called pediatric multi-system inflammatory syndrome (PMIS or PIMS), is a newly recognized, potentially serious illness in children that seems to be related to COVID-19.
The condition appears as a delayed complication of coronavirus infection, although not all children with MIS-C-related symptoms test positive for the virus.
the disease affects several organs and systems in the body. Many children have symptoms resembling toxic shock syndrome or Kawasaki disease, in which blood vessels, including the coronary arteries, enlarge or form aneurysms. Some children have signs of excessive blood clotting, gastrointestinal symptoms, kidney injury, neurologic symptoms, or heart inflammation with impaired heart function. These symptoms can occur in different combinations.
The cause of the disease is a delayed immune response to the coronavirus that somehow goes into overdrive, causing inflammation that damages organs. It’s also possible that the antibodies children make to the virus are creating the immune reaction
Dear Dr. Raya Al-Naimi Thanks a lot for your comment and contribution. Really thanks. Thanks for your kindness and support.
Yes .. my thought also is that the kind of Antibodies the Children body makes in response to the virus instead of a wild Cytokine storm is what causes the wild inflammation in many of these organs, i am still waiting to have a case of this in my country where we can investigate..
Dear Dr. Idowu Goodnews Oluwaseyi Thanks a lot for your comment and contribution. Really thanks. Thanks for your kindness and support.
Multisystem inflammatory syndrome in children (MIS-C) is a condition where different body parts can become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs. We do not yet know what causes MIS-C. However, we know that many children with MIS-C had the virus that causes COVID-19, or had been around someone with COVID-19. MIS-C can be serious, even deadly, but most children who were diagnosed with this condition have gotten better with medical care.
https://www.cdc.gov/coronavirus/2019-ncov/daily-life-coping/children/mis-c.html
Seek emergency care right away if your child is showing any of these emergency warning signs of MIS-C or other concerning signs:
Trouble breathing
Pain or pressure in the chest that does not go away
New confusion
Inability to wake or stay awake
Bluish lips or face
Severe abdominal pain
https://www.cdc.gov/coronavirus/2019-ncov/daily-life-coping/children/mis-c.html
This is the inflammatory response of the body in response to the SARS-cov2 virus. It may be lethal.
Multisystem inflammatory syndrome in children (MIS-C) is a serious condition in which some parts of the body — such as the heart, blood vessels, kidneys, digestive system, brain, skin or eyes — become inflamed. Inflammation typically includes swelling, often with redness and pain.
Many, but not all, children with MIS-C test negative for a current infection with the virus that causes COVID-19. Yet evidence indicates that many of these children were infected with the COVID-19 virus in the past, as shown by positive antibody test results.
An antibody test with a positive result means that the child's immune system developed blood proteins (antibodies) that fought the COVID-19 virus. Sometime this blood test is the only indication that the child was ever infected — meaning the child may have fought the infection without ever having shown signs or symptoms of COVID-19. Still, some children with MIS-C are currently infected with the virus, usually confirmed by detection of the virus on a swab taken from the back of the nose or throat.
MIS-C shares some of the same signs and symptoms as another condition called Kawasaki disease. Kawasaki disease mainly affects children under 5 years of age. It causes inflammation in the walls of blood vessels, particularly those that supply blood to the heart muscle (coronary arteries). Researchers are working to figure out if the two conditions are related or not.
https://www.mayoclinic.org/diseases-conditions/coronavirus/in-depth/mis-c-in-children-covid-19/art-20486809
How to help prevent your child from getting MIS-C
The best way to help prevent your child from getting MIS-C is to take action to avoid exposure to the COVID-19 virus and teach your child how to do the same. Follow the guidelines of the U.S. Centers for Disease Control and Prevention:
Keep hands clean. Wash hands often with soap and water for at least 20 seconds. If soap and water aren't available, use a hand sanitizer that contains at least 60% alcohol.
Avoid people who are sick. In particular, avoid people who are coughing, sneezing or showing other signs and symptoms that indicate they might be sick and contagious.
Practice social distancing. This means that you and your child should stay at least 6 feet (2 meters) from other people when outside of your home.
Wear cloth face masks in public settings. When it's difficult to practice social distancing, both you and your child — if he or she is age 2 years or older — should wear face masks that cover the nose and mouth.
Clean and disinfect high-touch surfaces every day. This includes areas of your home such as doorknobs, light switches, remotes, handles, countertops, tables, chairs, desks, keyboards, faucets, sinks and toilets.
Wash clothing and other items as needed. Follow manufacturers' instructions, using the warmest appropriate water setting on your washing machine. Remember to include washable plush toys.
https://www.mayoclinic.org/diseases-conditions/coronavirus/in-depth/mis-c-in-children-covid-19/art-20486809
Manal Hadi Kanaan
Multisystem inflammatory syndrome in children (MIS-C), also called pediatric multi-system inflammatory syndrome (PMIS or PIMS), is a newly recognized, potentially serious illness in children that seems to be related to COVID-19. For many children, it appears to be a delayed complication of coronavirus infection, although not all children with MIS-C-related symptoms test positive for the virus.
http://www.childrenshospital.org/conditions-and-treatments/conditions/m/mis-c
Dear Dr. Nirmala S.V.S.G Thanks a lot for your comment and contribution. Really thanks. Thanks for your kindness and support.
Dear Dr. Chinaza Godswill Awuchi Thanks a lot for your comment and contribution. Really thanks. Thanks for your kindness and support.
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Dear Dr. Voskoboinick Andrey Thanks a lot for your comment and contribution. Really thanks. Thanks for your kindness and support.
Dear Dr. Harasit Kumar Paul Thanks a lot for your comment and contribution. Really thanks. Thanks for your kindness and support.
Pediatric multi-system inflammatory syndrome is a serious condition in which inflammation occurs in some parts of the body, such as the heart, blood vessels, kidneys, digestive system, brain, skin, or eyes. The inflammation usually leads to swelling, often with redness and pain.
And for the many children with multiple system inflammation syndrome, a negative Covid 19 test comes out. However, evidence indicates that many of these children had COVID-19 in the past, based on positive antibody test results.
When the antibody test result is positive, this means that the child's immune system has generated blood proteins (antibodies) that fight Covid 19. Sometimes this blood test is the only indication that the child has been infected previously - which means that the child's body may be He has fought off the infection without showing any signs or symptoms of Covid 19. However, some children with MS are currently infected with the virus, which is usually examined by a swab to detect the virus taken from the back of the nose or throat.
Dear Dr. Afraa Ibrahim Thanks a lot for your comment and contribution. Really thanks. Thanks for your kindness and support.
Dear Dr. Voskoboinick Andrey Thanks a lot for your comment and contribution. Really thanks. Thanks for your kindness and support.
you may have heard about a serious inflammatory syndrome in children, including some teenagers, that appears to be linked to COVID-19 . It's called multisystem inflammatory syndrome in children ( MIS-C ). This syndrome is rare, and most children who have it eventually get better with medical care.
https://www.google.com/search?q=multisystem+inflammatory+syndrome+in+children+%28MIS-C%29%3F+and+who+is+at+risk%3F&client=ucweb-b&channel=sb
Children and some teenagers are at risk of MIS-C
https://www.cdc.gov/mis-c/
Dear Dr. Chinaza Godswill Awuchi Thanks a lot for your comment and contribution. Really thanks. Thanks for your kindness and support.
Multi-system inflammatory syndrome in children (MIS-C) is a condition where different body parts can become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs. Children with MIS-C may have a fever and various symptoms, including abdominal (gut) pain, vomiting, diarrhea, neck pain, rash, bloodshot eyes, or feeling extra tired. We do not yet know what causes MIS-C.
Dear Dr. Ruaa SH Redeiny Thanks a lot for your comment and contribution. Really thanks. Thanks for your kindness and support.
Multisystem inflammatory syndrome in children (MIS-C) is a condition where different body parts can become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs. Children with MIS-C may have a fever and various symptoms, including abdominal (gut) pain, vomiting, diarrhea, neck pain, rash, bloodshot eyes, or feeling extra tired.
Dear Dr. Khaleel Z. K. Al-Alo Thanks a lot for your comment and contribution. Really thanks. Thanks for your kindness and support.
Pediatric multi-system inflammatory syndrome (MISC-Ces is a serious disease in which parts of the body become inflamed - such as the heart, blood vessels, kidneys, digestive system, brain, skin, or eyes. Inflammation usually includes swelling, often with redness and pain.
Many, but not all, children with MISC-C test negative for current infection with the virus that causes COVID-19. But evidence indicates that many of these children have been infected with the COVID-19 virus in the past, as shown by their antibody test results.
A positive antibody test means that the child's immune system has developed proteins in the blood (antibodies), which fight the COVID-19 virus. Sometimes this blood test is the only indication that the child has been infected - meaning that the child may have fought the infection without showing signs or symptoms of COVID-19. But some children with MISC-Ca are infected, which is usually confirmed by detecting the virus on a swab with a sample taken from the back of the nose or throat.
MISC-C shares some of the same signs and symptoms with another condition known as Kawasaki disease. Kawasaki disease mainly affects children under 5 years of age. It causes inflammation of the walls of the blood vessels, particularly those that supply blood to the heart muscle (coronary arteries). Researchers are working to determine if the two conditions are related, or if they are not.
The signs and symptoms of pediatric multisystem inflammatory syndrome include those listed below, although not all children have the same symptoms: Fever lasting 24 hours or longer, Vomiting, Diarrhea, Stomach pain, Rash, Red eyes
Redness or swelling of the lips and tongue, Feeling unusually tired, Redness or swelling in the hands or feet
Signs that warn of an emergency for MISC-C include:
Inability to wake up or stay awake, Difficulty breathing, Chest pain or pressure that does not go away, Confusion that is new
Bluish lips or face, severe stomach pain
Dear Dr. Francisco Javier Gala Thanks a lot for your comment and contribution. Really thanks. Thanks for your kindness and support. I am so grateful for you Doctor.
Another concern regarding the epidemic of SARS-CoV-2 around the world in relation to children is the association between COVID-19 and multisystem inflammatory syndrome in children (MIS-C). Recently, patients with COVID-19 have been observed with a syndrome that is very similar to Kawasaki syndrome [18]. In previously healthy children between the ages of 5 and 19
years, severe cases of COVID-19 were found, many of which had a positive COVID-19 antibody test and showed toxic shock-like syndrome or Kawasaki-like syndrome characteristics. The term multisystem inflammatory syndrome (or MIS-C) was given to this condition by the Centers for Disease Control and Prevention (CDC) [19]. Similar cases have been reported around the world and warnings have been issued. MIS-C affects various organs [20]. Prolonged fever, skin rash, lymphadenopathy, diarrhea and elevation of inflammatory biomarkers are the common symptoms between MIS-C and Kawasaki disease
[18]. Left ventricular systolic dysfunction and acute heart failure, and fewer abdominal disorders, are symptoms of MIS-C. One of the most common causes of acquired heart disease in developed countries is Kawasaki syndrome [21]. Various factors have been suggested as a trigger of Kawasaki syndrome but the most important trigger is some infectious agents. In people with a specific genetic predisposition, some infectious agents can prompt the clinical manifestations of the disease [18,20]. Unfortunately, the exact cause of Kawasaki syndrome has not been determined. The current idea is that an immunological response to exposure in the respiratory system or gastrointestinal tract or both can lead to Kawasaki syndrome in children who are genetically susceptible [22]. Systematic inflammation is a result of the immunological cascade in multiple organs and in medium-sized arteries when the syndrome is
in the acute phase [18,21].
You can find more information about the differences between children and adults COVID-19 involvement in this article:
Article Exploring the causes of mild COVID-19 involvement in pediatr...
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Multisystem inflammatory syndrome in children (MIS-C) is a condition where different body parts can become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs.Many children with MIS-C had the virus that causes COVID-19, or had been around someone with COVID-19. MIS-C can be serious, even deadly, but most children who were diagnosed with this condition have gotten better with medical care.
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Mohammed I. Rushdi
Multisystem inflammatory syndrome in children (MIS-C) is a condition where different body parts can become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs. We do not yet know what causes MIS-C. However, we know that many children with MIS-C had the virus that causes COVID-19, or had been around someone with COVID-19. MIS-C can be serious, even deadly, but most children who were diagnosed with this condition have gotten better with medical care.
https://www.cdc.gov/coronavirus/2019-ncov/daily-life-coping/children/mis-c.html
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