Definition and Background of Helicobacter Pylori Infections
Helicobacter pylori (H. pylori) bacterium is involved in many diseases other than peptic ulcer disease, such as coronary artery inflammation, gastroesophageal reflux disease, skin disease, iron deficiency anemia, rheumatologic issues and lymphoid tissue lymphomas associated with mucosa. It has also been reported that there is a strong association between gastric adenocarcinoma and lymphoma and H. pylori bacterium.
Well Helicobacter pylori (H. pylori) is probably the mostly recognized bacteria causing infection related to the genesis of both PUD and gastric cancer.
H.Pylori is the main infectious agent for causing peptic ulcer disease and gastric ca.
H. pylori is very strong associated with PUD, but and with MALT low malignity, who its eradication give very good results in the regression of this pathologic condition, but not in MALT with high malignity. Approximately 70% is associated with gastric carcinoma, especially adenocarcinoma.
this bacteria is endemic in all world population and around 40-50% of us harbor it in our upper gastro-intestinal tract even without symptoms which is appears after imbalance in our immune response or the bacteria acquires new proteolytic enzymes like urease , here and only here it becomes pathogenic and could be blamed to the mentioned diseases.
Helicobacter pylori infection is a common worldwide infection that is an important cause of peptic ulcer disease and gastric cancer.
Chapter Peptic Ulcer Disease
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Article The Clinical Evidence Linking Helicobacter pylori to Gastric Cancer
Article H. pylori infection and gastric cancer: State of the art (Review)
Please also take a look at this link.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952980/
Helicobacter pylori infection is now recognized as an important causative factor in both peptic ulcers and gastric cancer
Article The Risk of Stomach Cancer in Patients with Gastric or Duode...
That is very important causative factor for PUD and low malignancy MALT and gastric carcinoma (in 1994 WHO known as carcinogen) known since 1982/83.
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