Inflammatory mediators promote insulin resistance, suggesting perhaps that critical care patients may exhibit hyperinsulinemia. However, I have great difficulty finding an article referring to serum insulin levels (there is an overabundance of publications on hyperglycaemia and insulin resistance but not insulin).
I would very much appreciate it if anyone can refer me to a manuscript making reference on insulin levels in any severe inflammatory setting (burns, sepsis, trauma, and surgery… any context where a strong inflammatory response is solicited).
Note: hyperglycaemia is often treated with intensive insulin therapy –it would be super if the study refer to untreated patients.
There are as you say,loads of articles referring to hyperinsulinaemia,but few which look directly at insulin levels.
This may be of some use hopefully...
Article Hyperglycemia in Children with Meningococcal Sepsis and Sept...
Article Blood insulin response to blood glucose levels in high outpu...
The conclusions indicate a difference in terms of either hypoinsulinaemia or insulin resistance,dependant on the response to sepsis,but the number of papers is obviously small.
Hope that's of some use....
Best regards,
Ian
Hi Ian, many thanks!
Honestly, I was absolutely smitten as why I could not find any reference to serum insulin levels. However, that there is in fact not many publications on this topic is even stranger though...
In any case, articles definitely seem relevant. Will most certainly have a closer look -thanks!
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