Can anyone share their Ideas about Pharmacological Research Work without Animal Use?

I am a Pharmacologist - Academician and would like to know and work on some Pharmacological research work which I can do at College level without use of any animal model. I mean to say some...

02 March 2016 5,566 2 View

Can anybody provide me with the best reference for how to perform half saturation test and full saturation test for protein?

07 August 2014 2,484 4 View

What could be a better alternative of experiments on isolated tissues of an animal (rat)? Are there any software to be used for a demonstration?

If we want to demonstrate the experiments on isolated rat ileum or any other isolated tissue, then do anybody have better alternate of this without dissecting a rat? If any software is available...

07 August 2014 140 1 View

Can anybody suggest any free download website for animated 3D screensaver?

I want to add animated 3D screensaver in Windows 8. Can anybody suggest any official and free website for this?

04 May 2014 4,441 0 View

Free software to conduct an online quiz?

From the last few months, I am trying to generate an online Quiz for my student, I have prepared some of them also, but find two difficulties: 1. Some students can't open the exam in their...

11 December 2013 1,466 4 View

How to measure cAMP level by simple laboratory technique or by diagnostic Kit?

I am checking cardiotonic activity & to perform in vitro study I need to measure cAMP level, for that I am searching for simple techniques which can be performed at laboratory level or best Kit...

09 October 2013 6,002 4 View

Shortcut key to merge some cells in table & to split the same!

Can anybody suggest the shortcut keys for Merging & splitting the cell in MS word & MS Excel?

09 October 2013 1,324 14 View

Can anybody suggest all the steps of fermentation processes required to synthesis Cynocobalamine?

If possible, give the detailed steps of fermentation process for Cynocobalamine with suitable reference.

08 September 2013 605 1 View

Can anybody suggest some in vitro models to check cardiotonic activity?

I want to check the cardiotonic activity of some plants. For screening of these plant I want some in vitro models (other than Langendorff's apparatus) which can be performed at laboratory scale.

08 September 2013 8,327 3 View

Which biomarkers can be useful to evaluate sedative & hypnotic activity?

I have evaluated Sedative, CNS-depressant, SKM relaxant as well as anxiolytic activity of one herb. To check sedative effect, I used Phenobarbital induce sleep model. Now, I would like know that...

07 August 2013 9,477 4 View

Can two EC50 values with different hill slopes be compared?

Hello, I fit a classical dose response curve Y=Bottom + (Top-Bottom)/(1+10^((LogEC-X)*HillSlope)) to my data (not related to inhibitors etc). The model I use is purely qualitative but it fits...

23 February 2021 8,155 5 View

Is this grounds for theophylline toxicity even though her plasma is within the therapeutic range? if it is, how is that possible?

A patient was given 300 mg Theophylline taken twice a day for the treatment of her bronchial asthma and has a positive clinical response. She has been compliant in taking her medication however,...

09 February 2021 3,489 3 View

Difference between assessing EC50 in presence of physiological levels of human serum albumin and alpha1 acid glycoprotein vs. % human serum?

01 February 2021 1,825 1 View

How can we increase awareness about Covid 19 prevention in our city among the local population?

The general public must be made aware of the mode of transmission, presenting symptoms and the measures that can be undertaken to prevent the spread of infection. Few options- Media, Webinars...

03 January 2021 3,538 13 View

Are the receptor proteins on the surface of infected cells will increase or decrease the susceptibility of antivirals?

Are the receptor proteins on the surface of infected cells will increase or decrease the susceptibility of antivirals?

22 December 2020 3,242 4 View

How can I reduce the viscosity of corn oil used as vehicle for administration in animal experiments?

Dear all, I am using corn oil as vehicle for subcutaneous injection and I want to reduce the viscosity of the vehicle (corn oil) to enhance the delivery of the main compound of interest....

18 December 2020 1,773 6 View

How to convert Terapeutic Human Doses to Cell Experimentation Doses?

"Toxicological evaluations revealed that Cur is found to be pharmacologically safe, even up to 12 g per day, as reported by several animal studies and in phase-I clinical trials Similarly,...

07 December 2020 3,012 1 View

How to increase presynaptic neurotransmitter release artificially?

I would like to pharmacologically increase presynaptic neurotransmitter release in mice CNS in vivo (through the extracellular micro-infusion of a compound). Which strategy would you recommand?...

02 November 2020 5,645 3 View

No title

30 October 2020 961 3 View

Poly ICLC or Poly IC structure for docking ?

I want to do docking of Poly ICLC with protein. But, unfortunately there is no crystal structure for Poly ICLC or poly IC. Poly ICLC is a complex of Poly IC, poly lysine, and...

24 September 2020 6,107 1 View