The most common neurological complaints in COVID-19 are anosmia, ageusia, and headache, but more serious complications, such as stroke, impairment of consciousness, seizures, and encephalopathy, have also been reported. They are rapidly reversible in most patients (of course the mild ones) but Long COVID-19 may be a serious problem. The long-term health consequences of COVID-19 were also evaluated in 1733 patients with COVID-19 in Wuhan, China. Six months following hospital discharge, the main persist-ing symptoms were fatigue or muscle weakness (1038/1655, 63%), sleep difficulties (437/1655, 26%) and anxiety or depression (367/1733, 23%). In addition, 76% of patients (1265/1655) declared at least one persisting symptom.Article Articles 6-month consequences of COVID-19 in patients discha...

Michał Pruc Thanks a lot for your answer , yes both of central and peripheral neurological complication

Having only met with pieces of evidence that showed that serious neurological COVID-19 complications were vascular in origin, I wonder whether the infection was also shown to attack, and damage, neurons themselves.

Francisco Forteza, for all I know (from the given autopsy and neuroimaging/MRI evidence), excepting smell impairment, all of the most common neurological manifestations of Covid-19 you quote are preferentially caused by vascular affections.

Are there any data on how far our virus advances along olfactory neurons or possibly beyond?

In accordance with Arnold Kriegstein, ( UCSF) the SARS-COV-2 infect the astrocytas and in accordance with other theory, the receptors of preicitas (in the blood vessels) are blocked by the SARS COV 2 and provoke vasoconstriction. That why the smaller blood vessels in the brain are affected and the deteriorating circulation of the brain is cause the neurogical symptoms.

Hasanain A. Al-Khalidi Find about neurological manifestations at PMID: 32761396

But, Nida Fatima, needn't we make sure first which kind of agent is precisely at work - and where, via which histological and biochemical entities? Aren't questions of the biomechanics of primary relevance here?

Must there not be made sure what neurological manifestations are caused by?

You can find your answer from https://www.uptodate.com/contents/covid-19-neurologic-complications-and-management-of-neurologic-conditions#:~:text=Other%20less%20common%20complications%20of,acute%20neurologic%20manifestations'%20below.)

This link offers indeed quite a deal of answers, MM Rahman.

But which one do you consider satisfactory?

The comment on Covid MRI findings maybe?

Have a look at the following RG links for insights.

Article Neurological complications associated with Covid‐19; molecul...

Article Acute and Post-Acute Neurological Complications of COVID-19

Even mild SARS-CoV-2 infection can cause brain shrinkage, memory loss and long term brain damage.

https://www.nature.com/articles/s41586-022-04569-5

https://europepmc.org/article/med/32329044